（蛋白质多肽材料的潜力：从蜘蛛丝到基因传递）

报告人： Prof. Dr. Keiji Numata, Team leader in RIKEN(日本理化学研究所)

报告时间： 10:00-12:00, 22 June 2017

报告地点： 威尼斯国际交叉科学研究院IRC 308

报告人简介：Dr. Numata earned his Ph.D. (2007) with a thesis on enzymatic synthesis and degradation of biopolymers, e.g. poly(hydroxyalkanoate), using hydrolases. His Ph.D. work on enzymatic polymerization to synthesize branched biopolymers was performed in the Royal Institute of Technology (Sweden) under the supervision of Prof Ann-Christine Albertsson and Associate Prof. Anna Finne-Wistrand. Dr. Numata then became a JSPS Postdoctoral Fellow to work at the Biomedical Engineering Department at Tufts University (USA) and closely collaborated with Prof. David L. Kaplan - the Stern Family Professor in Engineering. De. Numata was fascinated by the biosynthesis of silk-based polymers via bacterial pathways as well as gene carriers of silk biopolymers. In 2010 he returned to Japan and started as a senior scientist at the Laboratory for Enzyme Research at RIKEN. His new research focuses on the design and bio-syntheses of poly(amino acid), polypeptide and structural proteins. He has become the Team Leader (PI) of the lab since 2012, and the Research Director of JST-ERATO Numata Organelles’ Reaction Cluster Project (1 Billion JPY) since 2016.

报告摘要： High-performance biological materials in nature are mainly composed of amino acids. Polymer of amino acids, namely, polypeptide has therefore been recognized as bioactive and functional material, however, use of those biopolymers as structural materials is still challenging. One of the major drawbacks of polypeptide-based materials is their limited synthesis method. My research group has successfully synthesized various polypeptides, even with unnatural amino acids or nylon units, via chemo-enzymatic polymerization. Those artificial polypeptides containing unnatural units achieve several properties that cannot be done by natural polypeptides. This synthesis method provides a new insight for material design of polypeptide. Furthermore, the designed polypeptides can be used as structural materials like spider silks and as functional materials including gene carriers for gene therapy and organellar engineering in eukaryotes. In this lecture, the current progress on the materials design of polypeptide will be introduced and reviewed.

联系人：管娟(15810741731) 邮箱：juan.guan@buaa.edu.cn